|
KMID : 0380620200520020138
|
|
Korean Journal of Food Science and Technology
2020 Volume.52 No. 2 p.138 ~ p.143
|
|
|
The protective effects of polyphenol-rich black chokeberry against oxidative stress and inflammation
|
|
Jeon So-Hyeon
Kim Bo-Kyung
|
|
|
Abstract
|
|
|
|
Black chokeberry (Aronia melanocarpa) has been suggested to exert antioxidant and anti-inflammatory effects due to its high polyphenol content. However, the mechanisms underlying the effects of black chokeberry on the alterations of nuclear factor E2-related factor 2 (NRF2) and nuclear factor κB (NF-κB) in macrophages have not been thoroughly studied. In this study, we investigated the protective effects of polyphenol-rich black chokeberry extract (CBE) against lipopolysaccharide (LPS)-induced oxidative stress and inflammation in RAW 264.7 macrophages. CBE significantly attenuated the increase of cellular reactive oxygen species (ROS) levels and the nuclear translocation of NRF2 in LPSstimulated macrophages. The mRNA abundances of Nrf2 and its downstream antioxidant genes were significantly decreased in LPS-stimulated macrophages. The LPS-induced mRNA expression of proinflammatory cytokines was significantly inhibited by reducing the nuclear translocation of NF-κB by CBE. These data suggest that black chokeberry may be used for the prevention of oxidative stress and inflammation-associated disease.
|
|
|
KEYWORD
|
|
|
Black chokeberry, Aronia melanocarpa, oxidative stress, inflammation, macrophages
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|